Selected Publications
Su, D., Cha, Y.M., and West, A.E. (2012) Mutation of MeCP2 enhances RNA Polymerase II binding and increases cocaine-inducibility of select immediate-early gene promoters. Epigenetics. In Press.
Hutchinson, A.N., Deng, J.V., Aryal, D.K., Wetsel, W.C., and West, A.E. (2012) Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Neuropsychopharmacology. 37:321-337.
Cohen, S., Gabel, H.W., Hemberg, M., Hutchinson, A.N., Sadacca, L.A., Ebert, D.H., Harmin, D.A., Greenberg, R.S., Verdine, V.K., Zhou, Z., Wetsel, W.C., West, A.E. and Greenberg, M.E. (2011) Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and cognitive function. Neuron. 72: 72-85.
West, A.E. and Greenberg M.E. (2011) Neuronal activity-regulated gene transcription in synapse development and cognitive function. Cold Spring Harb Perspect Biol. 3: a005744.
Lyons, M.R. and West, A.E. (2011) Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog. Neurobiol. 94: 259-295.
West, A.E. (2011) Biological functions and transcriptional targets of CaRF in neurons. Cell Calcium. 49:290-295.
Deng, J.V., Rodriguez, R.M., Hutchinson, A.N., Kim, I.-H., Wetsel, W.C., and West, A.E. (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nat. Neurosci. 13: 1128-1136. PMC2928851.
Pfenning, A.R., Kim, T.-K., Spotts, J.M., Hemberg, M., Su, D., and West, A.E. (2010) Genome-wide identification of Calcium-Response Factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. PLoS One, 5: e10870.
McDowell, K.A., Hutchinson, A.N., Wong-Goodrich, S.J.E., Presby, M.M., Su, D., Rodriguiz, R.M., Law, K.C., Wiliams, C.L., Wetsel, W.C., and West, A.E. (2010) Reduced cortical BDNF expression and aberrant memory in Carf knockout mice. J Neurosci, 30: 7453-7465.
Kokobu, M., Nishio, M., Ribar, T.J., Anderson, K.A., West, A.E., and Means, A.R. (2009) BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. J. Neurosci. 29: 8901-8913.
Chen, W.G., Chang, Q., Lin, Y., Meissner, A., West, A.E., Griffith, E.C., Jaenisch, R., and Greenberg, M.E. (2003) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science. 302: 885-889.
Tao, X.*, West A.E.*, Chen, W.G., Corfas, G., and Greenberg, M.E. (2002) A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron, 33: 383-395.
Bonni, A., Brunet, A., West, A.E., Datta, S.R., Takasu, M.A., and Greenberg, M.E. (1999). Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science, 286: 1358-1362.
Hutchinson, A.N., Deng, J.V., Aryal, D.K., Wetsel, W.C., and West, A.E. (2012) Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Neuropsychopharmacology. 37:321-337.
Cohen, S., Gabel, H.W., Hemberg, M., Hutchinson, A.N., Sadacca, L.A., Ebert, D.H., Harmin, D.A., Greenberg, R.S., Verdine, V.K., Zhou, Z., Wetsel, W.C., West, A.E. and Greenberg, M.E. (2011) Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and cognitive function. Neuron. 72: 72-85.
West, A.E. and Greenberg M.E. (2011) Neuronal activity-regulated gene transcription in synapse development and cognitive function. Cold Spring Harb Perspect Biol. 3: a005744.
Lyons, M.R. and West, A.E. (2011) Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog. Neurobiol. 94: 259-295.
West, A.E. (2011) Biological functions and transcriptional targets of CaRF in neurons. Cell Calcium. 49:290-295.
Deng, J.V., Rodriguez, R.M., Hutchinson, A.N., Kim, I.-H., Wetsel, W.C., and West, A.E. (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nat. Neurosci. 13: 1128-1136. PMC2928851.
Pfenning, A.R., Kim, T.-K., Spotts, J.M., Hemberg, M., Su, D., and West, A.E. (2010) Genome-wide identification of Calcium-Response Factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. PLoS One, 5: e10870.
McDowell, K.A., Hutchinson, A.N., Wong-Goodrich, S.J.E., Presby, M.M., Su, D., Rodriguiz, R.M., Law, K.C., Wiliams, C.L., Wetsel, W.C., and West, A.E. (2010) Reduced cortical BDNF expression and aberrant memory in Carf knockout mice. J Neurosci, 30: 7453-7465.
Kokobu, M., Nishio, M., Ribar, T.J., Anderson, K.A., West, A.E., and Means, A.R. (2009) BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. J. Neurosci. 29: 8901-8913.
Chen, W.G., Chang, Q., Lin, Y., Meissner, A., West, A.E., Griffith, E.C., Jaenisch, R., and Greenberg, M.E. (2003) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science. 302: 885-889.
Tao, X.*, West A.E.*, Chen, W.G., Corfas, G., and Greenberg, M.E. (2002) A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron, 33: 383-395.
Bonni, A., Brunet, A., West, A.E., Datta, S.R., Takasu, M.A., and Greenberg, M.E. (1999). Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science, 286: 1358-1362.